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Xin-Hai Wang

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Oct 2026

Discovery of a BBB-Penetrant Lanosterol Derivative as an Aβ Aggregation Inhibitor for Alzheimer’s Disease

The abnormal aggregation of amyloid-beta (Aβ) peptides is a core driver of Alzheimer’s disease (AD). Developing central nervous system (CNS)-penetrant small-molecule Aβ inhibitors offers a complementary strategy to overcome the high costs and severe side effects of antibodies. Lanosterol has demonstrated excellent po...

Bai-Chen Xiong, Teng-Fei Zhen, Xin-Hai Wang et al. · 0 citations

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