Oct 2026
Cell-cycle-driven noncanonical ubiquitination of METTL14 orchestrates RNA methylation.
Jie Cao, Xin-Er Ying, Li-Li Zhou et al.
· Nature Chemical Biology · 0 citations
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Sep 2026
Follistatin drives AR-independent prostate cancer through BMP signaling inactivation and microenvironmental remodeling.
Resistance to androgen receptor (AR)-targeted therapies remains a major clinical challenge in advanced prostate cancer. Here we identify follistatin (FST), TGFβ superfamily antagonist, as a key driver of AR-independence and treatment resistance. During anti-AR therapy, cancer cells progressively lose the positive feedb...
Xiao-Xian Shi, Zu-Yan Fan, Min Qu et al.
· Proceedings of the National... · 0 citations