Xin-Jie Liu

Macrophages diverge into profibrotic SAMs and proresolving ReM2 cells to regulate liver fibrosis.

A central question in liver fibrosis is how macrophages, key regulators of inflammation and tissue repair, are divergently programmed to either promote scar formation or drive its resolution. Here, we identify a macrophage axis that governs this balance. While scar-associated macrophages (SAMs) promote fibrogenesis thr...