Review
Open access
Sep 2026
O-GlcNAcylation: A Metabolic-Immune Hub Regulating Macrophage Fate and Osteoclast Differentiation.
BACKGROUND O-GlcNAcylation is a dynamic and reversible post-translational modification of serine/threonine residues on cytoplasmic and nuclear proteins. Although it has been implicated as a "differentiation switch and functional regulator" in osteoclast biology, a systematic synthesis of its role across the macrophage-...
Jing Zhang, Kun-Ru Tian, Nan Zhuang et al.
· Oral Diseases · 0 citations