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Author

Xin Liu

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4 papers indexed here

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Oct 2026

Pharmacokinetic Modeling and Dosing Simulations of Temocillin in Children With Urinary Tract Infections.

BACKGROUND Temocillin, active against most extended-spectrum β-lactamases (ESBL)-producing Enterobacterales, is increasingly considered a carbapenem-sparing option for Gram-negative infections. Despite a recommended pediatric dose of 25-50 mg/kg/d in 2 administrations, its pharmacokinetics in children remain ill charac...

Xin Liu, Perrin Ngougni Pokem, M. Hainaut et al. · 0 citations
Sep 2026

Optimization of meropenem and piperacillin dosing during CRRT interruption and liberation in critically ill patients: an in silico sub-study from the SMARRT Study.

This Monte Carlo simulation used validated population pharmacokinetic models from the SMARRT study to optimize meropenem and piperacillin dosing during 6-h and 24-h interruptions and liberation from continuous renal replacement therapy (CRRT).

Lin-Na Zhang, Manuel Colmenero, Xin Liu et al. · 0 citations
Open access Sep 2026

Vancomycin population pharmacokinetics and optimized dosing in critically ill infants and children.

BACKGROUND Vancomycin dosing remains challenging due to narrow therapeutic window and pharmacokinetic (PK) variability in critically ill children. This study aims to characterise pediactric vancomycin PK, identify significant covariates, and optimise dosing strategies. METHODS Vancomycin plasma concentrations from pa...

T. Dorofaeff, Xin Liu, E. Novy et al. · 0 citations

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