Chronic inflammation is a central driver of diverse human diseases, including autoimmune, metabolic, neurodegenerative, and cardiovascular disorders. Although current anti-inflammatory therapies have substantially improved disease control, important unmet needs remain because of incomplete or variable responses, long-t...
Ye Wu, Ji-Yuan Zhang, Qing-Yi Xiong et al.· Immunity & Inflammation· 0 citations
Targeting CTGF+ CAFs with QX03-46 significantly disrupted the CTGF/TGF-β1 signaling axis and suppressed CAF functions, resulting in decreased extracellular matrix deposition and oncogenic cytokine secretion and position QX03-46 as a promising therapeutic candidate for targeting the fibrotic TME.
Yi-Wen Shen, Qing-Yan Sun, Yun-Zhe Wang et al.· Proceedings of the National...· 0 citations
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