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Xin-Miao Lu

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Review Open access Oct 2026

Steroid 5α-reductase type 1 as a neurodevelopmental toxicological target: Hydrophobicity governs environmental inhibition within, but not across, chemical classes.

Steroid 5α-reductase type 1 (SRD5A1) catalyzes the rate-limiting reduction of progesterone to 5α-dihydroprogesterone, the committed step toward allopregnanolone, a positive allosteric modulator of γ-aminobutyric acid type A (GABAA) receptors. Its clinical relevance is shown by allopregnanolone therapeutics for postpart...

Xin-Miao Lu, Jia-Qi Chen, Hao-Nan Fang et al. · 0 citations

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