Xin-Nan Liu

Tumor-intrinsic NSUN2 orchestrates immunosuppression in lung adenocarcinoma via the m5C-HDAC8-CCL5 axis

Findings identify NSUN2 as a critical orchestrator of T-cell exclusion in LUAD and serves as both a candidate predictive biomarker for ICI failure and a promising druggable target for immunotherapy resistance.

Targeting the FOXP3—T-bet interaction to restore Treg stability in IFN-γ—driven autoimmunity 2254306

Regulatory T cells (Tregs) maintain immune homeostasis through FOXP3-centered transcriptional complexes that tightly control lineage stability and suppressive function. However, how specific FOXP3 mutations disturb this complex and drive pathogenic Treg reprogramming in IPEX syndrome remains unclear. We identifie...

Targeting the FOXP3–T-bet interaction to restore Treg stability in IFN-γ–driven autoimmunity