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Xin-Ran Zhang

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Open access 2026

Transcriptional activation of ALOX5 by c-Myc drives malignant progression and M2 macrophage polarization in clear cell renal cell carcinoma.

Clear cell renal cell carcinoma (ccRCC) is an aggressive malignancy with poor prognosis, but the molecular mechanisms linking oncogenic signaling to macrophage polarization remain unclear. In this study, we identify arachidonate 5-lipoxygenase (ALOX5) as an oncogenic factor in ccRCC. Multi-omics analyses and clinical v...

Chang-Jie Ren, Yi-Jun Tian, Xin-Ran Zhang et al. · 0 citations

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