Author

Xin-Rong Yang

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Open access Sep 2026

Decomposition-driven biomarker identification enhances non-invasive early cancer detection

Summary Accurate marker selection in cell-free DNA (cfDNA) is essential for non-invasive early cancer detection, yet conventional approaches based on bulk tissue data often yield markers with limited efficacy in blood-based assays, due to the sparse and heterogeneous nature of tumor-derived cfDNA released into the bloo...

Wei-Zhong Chen, Ying-Hong An, Rui-Qing Fu et al. · iScience · 0 citations

Open access Aug 2026

Margin-enriched CD4+ central-memory T cells affect macrophages via ANXA1-FPR1 signaling axis to promote tumor progression in intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (iCCA) is the second most prevalent liver cancer with a high mortality and recurrence rate, and remains a poorly understood disease. The tumor margin, as the transition zone between normal tissue and tumor, was not appreciated before. We performed mass cytometry (cytometry by time of fli...

Zhi-Feng Jiang, Ao Huang, Run-Ze Miao et al. · International Journal on Bio... · 0 citations