piR-45962 exacerbates autophagic apoptosis in aged myocardial ischemia-reperfusion injury through modulation of the HNRNPH1/GATA5 signaling axis.
Myocardial ischemia-reperfusion (I/R) injury is a significant contributor to poor prognosis after myocardial infarction, and the degree of irreversible myocardial damage is closely related to age. In I/R injury, ischemic and hypoxic stress triggers the coordinated activation of apoptosis and autophagy in cardiomyocytes...