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Xin-Rui Lin

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Review Open access Oct 2026

GPR183-mediated immune cell positioning and function: an integrative perspective across ligand gradients, tissue environments, and disease stages

G protein-coupled receptor 183 (GPR183), also known as EBI2, is a chemoattractant receptor whose principal endogenous ligand is 7α,25-dihydroxycholesterol (7α,25-OHC). Its expression varies dynamically across immune-cell subsets and activation states. By sensing local 7α,25-OHC gradients, GPR183 converts tissue metabol...

Xin-Rui Lin, Xin-Yu Dong, Zhe Jiang et al. · 0 citations

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