KDM4A-Driven Epigenetic Reprogramming as a Central Nexus Linking Metabolic Adaptation, Immune Remodeling, and Therapy Resistance in Cancer.
This review synthesizes current mechanistic and translational evidence to present a unified framework in which KDM4A links metabolic adaptation, immune remodeling, and therapy resistance, and discusses therapeutic opportunities, rational combination strategies, and the emerging biomarker potential of KDM4A-centered pat...