Xin Wang

In situ-formed pH-responsive hydrogel for sequential vascular disruption and Type I sonodynamic therapy-driven PANoptosis in hypoxic tumor therapy.

PANoptosis, an inflammatory cell death integrating pyroptosis, apoptosis, and necroptosis, has emerged as a promising approach for tumor immunotherapy. Reactive oxygen species (ROS) generation is the predominant strategy for triggering PANoptosis. However, in solid tumors, the hypoxic microenvironment suppresses ROS pr...