Open access
Sep 2026
Targeting PGAM1 Y119 phosphorylation resensitizes non-small-cell lung cancer to cisplatin therapy by promoting oxidative stress and DNA damage
Findings reveal a novel mechanism by which PGAM1 Y119 phosphorylation drives chemoresistance and suggest that targeting this phosphorylation event represents a potential therapeutic strategy to overcome cisplatin resistance in NSCLC.
Wen-Xia Zhang, Yan-Zhao Qu, Xin Wang et al.
· Journal of Biological Chemis... · 0 citations