Author

Xin-Xiang Chen

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Sep 2026

Biomimetic Nanoparticles Carrying EP300 Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible lung disease with limited treatment options. SGC-CBP30, a CBP/EP300 inhibitor, shows anti-fibrotic activity but suffers from poor bioavailability and tissue specificity. Here, we developed platelet membrane-coated nanoparticles (PNP) for targeted pulm...

Yong-Hang Fan, Jian-Fen Su, Zhi-Da Chen et al. · Molecular Pharmaceutics · 0 citations

Sep 2026

Quercetin protects against murine cytomegalovirus-induced pneumonia via suppression of viral replication and NLRP3 inflammasome activation.

Cytomegalovirus (CMV)-induced pneumonia is associated with excessive pulmonary inflammation and severe lung injury, particularly in immunocompromised individuals. Effective therapeutic strategies targeting both viral replication and inflammation-driven lung damage remain limited. Quercetin, a naturally occurring flavon...

Ping Sun, Xin-Xiang Chen, Xiao-Juan Wang et al. · Microbial Pathogenesis · 0 citations