Pancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive tumor microenvironment (TME) and poor prognosis. Although major histocompatibility complex class II (MHC-II) is typically expressed by professional antigen-presenting cells, its regulation and significance in malignant PDAC cells remain un...
Can-Ping Chen, Yi Zhang, Xi Li et al.· Cancer immunology research· 0 citations
Spatial omics technologies resolve molecular expression and spatial architecture at single-cell resolution, but profiling whole slides remains costly. In practice, only a few regions of interest (ROIs) are profiled, leaving the rest of the tissue unmeasured. S2-omics was the first framework to unify ROI selection with...
Sleep monitoring using wearable data has shown promise for personal health, yet large language model (LLM)-based summarization and question answering remain insufficient for personalized sleep guidance. Training specialized models, however, often requires costly expert annotation. Moreover, privacy and accessibility co...
Yu-Sheng Tan, Run-Ning Zhao, Sofia Angel et al.· 0 citations
A new prototype-based hierarchical alignment network (PHA-Net) to align individual/local/global level representations across modalities and introduces multiple modality-shared prototypes as the bridge to efficiently optimize text and video representations for cross-modal alignment.
Xiaolun Jing, Kezhao Yin, Xin-Xing Yang et al.· Neurocomputing· 0 citations
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