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Sep 2026

A Task-Adaptive Multimodal Pretrained Framework for Antibiotic Virtual Screening with Joint Activity and Cytotoxicity Prediction

Antimicrobial resistance (AMR) poses a growing threat to global public health, particularly for priority pathogens such as Staphylococcus aureus (SA) and Neisseria gonorrheae (NG), for which therapeutic options are increasingly limited. Although deep learning has accelerated antibiotic discovery, existing approaches...

Zhi-Jie Pan, Xin Yang, Wen-Chi Ge et al. · 0 citations
Open access Sep 2026

DECANT: decoupling mechanism from context in single-cell drug perturbation representation

Abstract Motivation Single-cell chemical perturbation profiling offers a powerful opportunity to organize drugs by shared mechanism-associated transcriptional responses, but observed transcriptional responses are entangled with contextual variation from cell identity, dose, and treatment time. As a result, models that...

Ren Qi, Wen-Jie Teng, Xin Yang et al. · 0 citations

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