The novel biguanide derivative 4C synergizes with talazoparib by inducing ferroptosis via the SREBP1/FASN/ SLC7A11/GPX4 axis in bladder cancer
Bladder cancer (BC) remains a clinically challenging urothelial malignancy, largely because a substantial proportion of patients have no effective treatment options. Epidemiological studies have shown that metformin can improve the survival rate of cancer patients. However, its clinical application is limited by th...