Author

Xinye Ni

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Open access Oct 2026

HSP90AA1 induces M2 macrophage polarization via stabilizing ITGB1 and promoting CCL2 secretion in nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) presents a major treatment challenge, largely due to immunotherapy resistance. The molecular mechanisms that drive the remodeling of the immunosuppressive tumor microenvironment (TME) in NPC are still not well understood. This study explored how heat shock protein 90 alpha family class...

Ming-Jun Ding, Chun-Sheng Wang, Xiang Cao et al. · Scientific Reports · 0 citations

Open access Jul 2026

ProtSyntax: a protein large language model for decoding post-translational modification syntax and function

ProtSyntax is introduced, a PTM-aware foundation protein language model combining protein-aware positional encoding, bidirectional state-space propagation, geometry-constrained attention and adaptive multi-objective learning that has the potential to decode the regulatory language of the modified proteome.

Yiyu Lin, Jiahui Wu, You Zhou et al. · bioRxiv · 0 citations