Tetramethylpyrazine ameliorates metabolic dysfunction-associated steatohepatitis by modulating gut microbiota dysbiosis and restoring intestinal barrier integrity.
BACKGROUND AND PURPOSE This study investigated the therapeutic effects and gut-liver axis-related mechanisms of tetramethylpyrazine (TMP) in metabolic dysfunction-associated steatohepatitis (MASH). EXPERIMENTAL APPROACH Male C57BL/6 mice were fed a methionine- and choline-deficient (MCD) diet for 6 weeks to establish...