The cannabinoid receptor type 2 (CB2) is a promising therapeutic target for neuroinflammatory diseases, whereas conventional orthosteric agonists suffer from poor selectivity and metabolic instability. Allosteric modulation, particularly by peptide-based modulators, offers a new strategy to overcome these limitations,...
Metal-catalyzed enantioselective construction of C(sp 3 )–O bonds from racemic alkyl electrophiles has attracted considerable attention, yet existing approaches typically proceed through organometallic or radical intermediates. Here, we highlight a halide-enabled dynamic kinetic resolution platform that integrates rapi...
Jin-Ze Du, Xin-Yi Zhang, Yu-Li He· Synlett : Accounts and Rapid...· 0 citations
A highly sensitive fluorescent biosensor for miRNA-34a detection by integrating magnetic separation with cascade amplification of duplex-specific nuclease (DSN) and hybridization chain reaction (HCR) and showing excellent specificity for discriminating against interfering miRNAs is developed.
Yan-Jie Zheng, Xin-Yi Zhang, Si-Yi Wang et al.· Nanomedicine: Nanotechnology...· 0 citations
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