Open access
Jul 2026
HUWE1 targets mitochondria via RMC1 to promote neurodevelopment.
The HECT-type E3 ubiquitin ligase HUWE1 is a critical regulator of protein homeostasis, genome stability, and neurodevelopment. Variants in HUWE1 are linked to X-linked intellectual disability (XLID), yet a significant number of HUWE1 variants are noncatalytic, leaving their disease mechanisms unresolved. Here, we iden...
Jia-Min Yi, Qin Yang, Chun Zhou et al.
· Proceedings of the National... · 1 citation