Xin-Yu Cao

Synthesis, herbicidal activity, crop selectivity, and in silico study of some new pyrazole-4-one derivatives

Targeting 4-hydroxyphenylpyruvate dioxygenase (HPPD) is a validated strategy for developing postemergence herbicides. In this work, nine new pyrazole-4-one derivatives L1-L9 were designed and synthesized through a prodrug approach based on the commercial HPPD inhibitor topramezone, wherein the isoxazole ring was opened...