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Xin-Yu Chen

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Open access Sep 2026

11-Oxo-mogroside V attenuates lung adenocarcinoma progression by disrupting metabolic homeostasis and suppressing TGFβ2/Myc-dependent oncogenic signaling

Highlights • 11-oxo-mogroside V suppresses LUAD progression in vitro and in vivo.• It disrupts metabolic homeostasis by reducing ATP, glucose, and LDH.• The compound induces G0/G1 arrest and promotes apoptosis in cancer cells.• It directly targets TGFβ2, HDAC1, and c-Myc to block oncogenic signaling.• Multi-pathway int...

Xin-Yu Chen, Li-Hua Yang, Jiao Li et al. · Translational Oncology · 0 citations