Ferroptosis is an iron-dependent form of regulated cell death driven by membrane lipid peroxidation and has become an important therapeutic vulnerability in cancer. The Hippo pathway, through its transcriptional effectors Yes-associated protein and transcriptional coactivator with PDZ-binding motif, links cell contact,...
Zi-Yi Xu, Ruo-Chen Yang, Huda Akram et al.· Frontiers in Medicine· 0 citations
The biological rationale for ferroptosis-targeted cancer therapy is summarized, major translational barriers are analyzed, and nanomedicine strategies that may move ferroptosis induction from experimental proof of concept toward clinically interpretable intervention are synthesized.
Yan-Pin Ma, Zi-Yi Xu, Huda Akram et al.· Frontiers in Molecular Biosc...· 0 citations
This review critically synthesizes the multifaceted roles of RNA modifications to bridge the gap between descriptive epitranscriptomic mapping and functional tumor biology, and aims to facilitate the translation of epitranscriptomic findings into clinical applications.
