Background Major depressive disorder (MDD) is highly prevalent in adolescents, and a substantial proportion of patients show inadequate response or limited tolerability to first-line treatments such as selective serotonin reuptake inhibitors and cognitive behavioral therapy, highlighting the need for additional treatme...
Hongyi Chen, Dan-Yu Xu, Wen-Jing Wang et al.· PLoS ONE· 0 citations
Current evidence indicates that interventions targeting the MGB axis should be approached cautiously and considered only as adjunctive strategies for the treatment of depression in this population, and future work requires rigorously designed, strain‐ and protocol‐specific clinical trials with standardised procedures,...
Hanchen Hou, Yi-Nan Li, Wanting Tang et al.· General Psychiatry· 0 citations
A topologically shifted WM functional connectome structure in adolescent MDD is revealed, providing new clues to aid in understanding the pathophysiology of its pathophysiology.