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Premature ovarian insufficiency (POI) is a heterogeneous disorder characterised by accelerated follicular depletion and ovarian dysfunction before age 40, yet effective therapeutic strategies remain limited. Here we identify the histone demethylase KDM3A (lysine‑specific demethylase 3A) as a critical protective factor...
Di(2-ethylhexyl) phthalate (DEHP) is a widespread plasticizer, but its role in subarachnoid hemorrhage (SAH) remains unclear. Integrating network toxicology, machine learning, transcriptomics, immune infiltration, molecular docking/dynamics, single-cell RNA sequencing, and in vivo/ in vitro experiments, we identified 2...
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