Xin-Yuan Ding

Transmembrane delivery of antimicrobial peptides by engineered eCIS into macrophages for intracellular mycobacteria elimination

Mycobacterium tuberculosis (M. tuberculosis, Mtb) is an intracellular bacterium persisting in macrophages, which can cause chronic infection and drug resistance. To address transmembrane limitation and improve treatment accuracy, we employed the Photorhabdus virulence cassette (PVC), a typical bacterial extracellular C...