Xin-Yuan Hu

A lipoprotein-responsive circular RNA, circCTCF, couples extracellular lipid availability to mTOR signaling via ACSL5 in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is an aggressive subtype with limited therapeutic options. While metabolic reprogramming is a hallmark of cancer, most studies have focused on cell-intrinsic alterations in glucose and amino acid metabolism, with comparatively little attention paid to how cancer cells sense and resp...