In Vitro and In Vivo Activity against Staphylococcus aureus and Pharmacokinetic Evaluation of a Novel Pleuromutilin Candidate.
Staphylococcus aureus infections pose a serious threat to public health, exacerbated by antimicrobial resistance and the limited pipeline of novel agents. Pleuromutilin, a natural antibiotic, provides a promising scaffold for developing new antibacterial agents via structural modification. To overcome the poor druggabi...