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Xin-Yue Wang

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Open access Oct 2026

Engineered receptor-biased IL-2-drug immunoconjugates selectively expand Tregs and suppress effector cells for autoimmune therapy.

Autoimmune and inflammatory diseases arise from a breakdown of immune tolerance driven by hyperactivation of effector lymphocytes and dysfunction of regulatory T (Treg) cells. Interleukin-2 (IL-2) supports both Treg maintenance and effector cell responses, necessitating careful dose optimization for selective immune re...

Jing Li, Shan-Bo Yang, Ye-Shuang Yuan et al. · Cell Reports Medicine · 0 citations

Open access Sep 2026

Nucleoside-modified circRNA: Reduced immunogenicity and expansive applications beyond vaccines

circRNA-based cancer vaccines and in vivo chimeric antigen receptor T (CAR-T) cell immunotherapies have been documented successively, but the issue of circRNA immunogenicity remains unresolved.

Xin-Yue Wang, Sheng-Nan She, Chi Zhang et al. · Molecular Therapy: Nucleic A... · 0 citations

Open access Jul 2026

IVT-free, chemically synthesized protein-encoding RNA oligonucleotides for rapid production of personalized cancer vaccines

A cap-independent translation enhancer BBV is introduced and protein-encoding RNA oligonucleotides (PEOs) are developed, chemically synthesized RNAs bearing 5’-OH and 3’-P termini that drive rolling circle translation after endogenous circularization that built an IVT-free platform for rapid, safe, and highly druggable...

Qian Pan, Chi Zhang, Xin-Yue Wang et al. · Proceedings of the National... · 0 citations