Jul 2026
Targeting tumor cell-intrinsic POU4F1 enhances antitumor immunity and sensitizes tumors to immunotherapy in basal-like breast cancer by modulating macrophage recruitment and polarization.
Mechanistic insights are provided into how POU4F1, a BLBC-specific transcription factor, orchestrates intercellular crosstalk to establish an immunosuppressive, tumor-supportive microenvironment, and indicate that targeting POU4F1 may represent a promising therapeutic strategy for BLBCs.
Jia-Hui Zhang, Nan-Yan Miao, Yun-Zhi Guo et al.
· Cancer Letters · 0 citations