Lgals3high Macrophages Orchestrate Neuroinflammation and Extracellular Matrix Remodelling via NF-κB Pathway in Acute Spinal Cord Injury.
BACKGROUND Acute spinal cord injury (ASCI) causes severe dysfunction, with secondary ECM remodelling being more destructive than primary injury. Macrophages regulate neuroinflammation and ECM remodelling in ASCI. Studies shown ECM related gene Lgals3 regulate macrophage polarization across various diseases. However, th...