Review
Open access
Aug 2026
The APOE4-estrogen-microglia axis in perimenopausal cognitive changes: mechanisms and therapeutic implications
A precision medicine framework for preventing or delaying neurodegenerative progression in high-risk perimenopausal women is proposed, centered on the APOE4-estrogen deficiency-microglia axis.
Liu-Qing Shi, Chun-Tong Zhou, Huan Han et al.
· Frontiers in Immunology · 0 citations