Xin Zhou

Exposure to Polystyrene Nanoplastics Induces Ferroptosis-Associated Cardiac Injury: Cell-Based Evidence for Lysosome-Associated NLRX1 Loss and an NLRX1–STING–NCOA4 Response

Tirzepatide attenuates cardiac microvascular injury and ferroptosis-related lipid peroxidation in diabetic mice: endothelial responses in the context of partial PRKN silencing.

BACKGROUND Diabetic metabolic stress damages the cardiac microvasculature. We evaluated tirzepatide-associated cardiac and endothelial effects, including endpoint patterns after partial silencing of parkin RBR E3 ubiquitin protein ligase (PRKN) and lipidated microtubule-associated protein 1 light chain 3 beta (LC3B-II)...

The integrated stress response in immune thrombocytopenia: from cellular stress to hematopoietic adaptation.

Immune thrombocytopenia (ITP) is an autoimmune hematologic disorder characterized by immune-mediated platelet destruction and impaired platelet production. In addition to these core abnormalities, ITP is associated with persistent inflammation, metabolic disturbance, oxidative injury, and altered proteostasis in immune...