Open access
Jul 2026
Development of a Novel AAV-Mediated microRNA Gene Therapy for Spatial Suppression of BACE1 to Improve Cognitive Function in Alzheimer’s Disease Model Mice
It is demonstrated that upregulation of BACE1 is correlated with downregulation of miR-143-3p in the hippocampus of individuals with AD, and miR-143-3p can directly target BACE1 to inhibit Aβ generation.
Ying Zhou, Yuelin Diao, Zhexiao Yan et al.
· Biomolecules · 0 citations