Activatable molecular probes in the second near-infrared (NIR-II, 900−1700 nm) window are sought-after for in vivo optical imaging and biosensing. However, current molecular skeletons are confined to a limited range of dye systems, including cyanine, hemicyanine, and xanthene derivatives. Herein, we report a series o...
Chen-Zhi Yao, Li-Wen Huang, Qian He et al.· Analytical Chemistry· 0 citations
Population aging has intensified interest in interventions that preserve function and delay disability. However, regenerative strategies for older adults are often discussed as isolated technologies, with limited attention to how aging biology alters therapeutic responses or how clinical benefit should be measured. W...
A heteroscedastic personalized regression framework is introduced to move beyond cohort-averaged associations and construct individualized single-nucleotide polymorphism (SNP) profiles for each subject, showing that model-derived individualized SNP-score profiles can reveal latent structure associated with cognitive an...
This review examines how machine learning, deep learning, natural language processing (NLP), and generative modeling are being applied across medicinal chemistry and drug development, and highlights how multimodal data fusion, predictive modeling, and human-AI collaborative frameworks are supporting more informed decis...
Kaicheng U, Sophia Meixuan Zhang, Ziyu Yu et al.· Chemical Society Reviews· 0 citations
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