Open access
Aug 2026
Spatial cholesterol homeostasis gatekeeps T-cell development and activation by orchestrating signaling and fitness
OSBP is identified as a central regulator of intracellular cholesterol transport that couples membrane cholesterol homeostasis to TCR signaling and ER integrity and is established as a fundamental metabolic determinant of thymocyte development and peripheral T-cell function.
Yanchi Li, Xing He, Chen-Xin Li et al.
· bioRxiv · 0 citations