Porcine reproductive and respiratory syndrome (PRRS) remains one of the most economically significant viral diseases affecting the global swine industry, and currently available commercial vaccines provide only limited protection against circulating PRRS virus (PRRSV) strains. Therefore, alternative vaccination strateg...
Lin-Xing Tian, Zheng-Dan Lin, Jia-Hui Ma et al.· Transboundary and Emerging D...· 0 citations
The serotypes and subtypes of foot-and-mouth disease virus (FMDV) are highly diverse, making the research and development of cross-protective and high-efficiency foot-and-mouth disease (FMD) vaccines increasingly urgent. In this study, we designed and constructed two mosaic nanoparticles by fusing porcine Ferritin (p...
Nan Cao, Ya-Mei Li, Xing-Hua Chen et al.· ACS Applied Nano Materials· 0 citations
Combined mutations at VP1 142 and 153 reshape viral antigenicity and act as core drivers of FMDV immune evasion, offering an experimental basis for clarifying FMDV evolution and developing broad‐spectrum vaccines.
Nan Cao, Ya-Mei Li, Xing-Hua Chen et al.· Transboundary and Emerging D...· 0 citations
An unbiased genome-wide CRISPR/Cas9 knockout screening using porcine cells reveals a ubiquitin-dependent RNF24-LPXN regulatory axis that supports FMDV entry, highlights the role of non-degradative ubiquitination in viral pathogenesis, and proposes this interface as a potential target for antiviral intervention.
Jin-Yan Zhang, Hai-Long Liu, Jian Du et al.· Frontiers in Cell and Develo...· 0 citations
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