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Author

Xing-Hua Gao

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Open access Oct 2026

PAK4 exacerbates melanoma immunosuppression by promoting exosome release.

Melanoma remains a lethal malignancy with frequent resistance to immune checkpoint blockade therapy. Clinical evidence associates elevated PAK4 expression with poor response to anti-PD-1 treatment in melanoma patients. While tumor-derived exosomes are recognized as key immunosuppressive mediators, the role of PAK4 in r...

Rui-Zhi Zhou, Tong Xu, Ze-Ming Shen et al. · 0 citations

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