Air Pollution Triggers Metabolomic Signature of Mitochondrial Dysfunction in Mice and Humans: Implications for Cardiovascular Disease Development
Background: Previous animal studies found that subchronic exposure to diesel exhaust (DE) induces hyperlipidemia, accompanied by upregulation of 12- and 15-lipoxygenase (LOX) pathways and hepatic mitochondrial dysfunction. However, the human relevance of these findings has not been established. Methods: We studied ApoE...