AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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Discovery of Novel Quinazoline-Based KDM1A Inhibitors as Dual Inducers of Ferroptosis and Apoptosis in Esophageal Cancer
In a KYSE510 xenograft model, oral administration of JH-1 significantly suppressed tumor growth without obvious toxicity and validate the quinazoline scaffold for epigenetic cancer therapy.
Targeting antibody-inaccessible immune resistance with small-molecule immunotherapy.
ICIs have revolutionized cancer treatment; however, the achievement of sustained clinical benefits is confined to a subset of patients due to inherent and acquired resistance mechanisms. Accumulating evidence suggests that tumor immune evasion is often sustained through intracellular, metabolic, epigenetic, and myeloid...