Xing-Jie He

Integrative single-cell and multi-omic analysis resolves granulosa-cell programs during chicken follicle selection.

Follicle selection sustains the hierarchical ovulatory cycle in laying hens, yet granulosa-cell (GC) programs have not been integrated across transcriptomic, regulatory and trait-genetic datasets. We integrated GC single-cell RNA-seq with independent bulk transcriptomes, ATAC-seq, Hi-C and ChickenGTEx GWAS/eQTL resourc...