Xing-Jie Zhang

Design and synthesis of quinazoline derivatives as novel JMJD3/HDAC dual-target inhibitors.

A series of novel quinazoline derivatives designed and synthesized as potent dual inhibitors targeting histone lysine demethylase JMJD3 and histone deacetylases provide a novel scaffold for dual-target epigenetic drug discovery, a valuable chemical probe for investigating epigenetic crosstalk, and a promising candidate...