Author

Xing-Lai Dai

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Open access Sep 2026

Multimodal AI and single-cell transcriptomics integrate to construct a histopathological prognostic model for bladder cancer, revealing the RTN3-glycolysis axis in chemoresistance

Bladder cancer is a common malignant tumor of the urinary system, and gemcitabine-based chemotherapy often fails because of drug resistance. Tumor heterogeneity, particularly copy number variations (CNVs) heterogeneity at the genomic level, is a core factor that drives disease progression and drug resistance. However,...

Shun-Li Yu, Ying-Jian Wang, Da-Peng Feng et al. · Experimental Hematology & On... · 0 citations

Open access Aug 2026

Integrative multi-omics reveals the POSTN+ CAF–APOE+ macrophage axis drives immunosuppression and progression in prostate cancer

An integrated single-cell atlas defines a critical POSTN+ CAF–APOE+ macrophage unit that is associated with a fibrotic and immunosuppressive TME in advanced prostate cancer, and suggested conserved enrichment and adverse prognostic impact of this stromal-immune axis across diverse tumor types, though tissue-specific co...

Yangzhou Liu, Ao-Chu Liu, Xing-Lai Dai et al. · Frontiers in Immunology · 0 citations