Simple Summary Toxoplasma gondii is a common parasite that infects humans and nearly all birds and mammals, posing a serious threat to immunocompromised individuals and pregnant women, and causing significant economic losses to the livestock industry. Its sexual reproduction occurs exclusively in cat intestines, a poor...
Xing Tian, Cheng Tian, Xin-Sheng Lu et al.· Animals· 0 citations
ABSTRACT Bile acid (BA) transformation relies on gut microbiota and is vulnerable to Toxoplasma gondii infection, yet feline microbial BA-transforming capacity upon toxoplasmosis remains unclear. Here, we constructed a catalog of 2,474 nonredundant feline gut microbial genomes and integrated serum metabolomic data to v...
Lu-Yao Tang, He Zhang, Ji-Xin Zhao et al.· Applied and Environmental Mi...· 0 citations
This study identifies L-lysine depletion as a metabolic feature of T. gondii infection and demonstrates that its supplementation confers measurable host-protective benefits, and supports the concept of L-lysine supplementation as a host-directed adjunctive intervention to mitigate pathology during toxoplasmosis.
The findings provide a novel metabolic perspective on the intestinal pathogenesis of toxoplasmosis and offer exploratory candidate lipid markers for diagnosing acute infection.
Wen-Jie Cheng, Bo-Fang Duan, Cai-Qin Deng et al.· Microorganisms· 0 citations
PruΔap2X-1 represents a potential live-attenuated vaccine candidate against toxoplasmosis, with a favorable safety profile observed under the experimental conditions, and induces a strong Th1-biased cellular and humoral immune response.
Wen-Bo Hao, Li-Xiu Sun, Ru-Shi Tu et al.· Animals· 0 citations
A comprehensive protein map is plotted that offers new insights into gut defense mechanisms and may help guide future efforts to develop therapies that modulate the host response rather than targeting the parasite directly.
Zhi-Lin Li, Yu-Xin Zhang, Pei-Lin Wang et al.· Biology· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
