Open access
Sep 2026
Halo: a pretrained model for whole-cell segmentation from nuclei images in spatial transcriptomics
Abstract Spatial transcriptomics (ST) enables measurement of gene expression while preserving spatial organization within tissues. Accurate reconstruction of single-cell transcriptomes requires precise whole-cell segmentation, yet many ST experiments provide only nuclear staining images, making reliable inference of ce...
Xing-Yuan Zhang, Hao-Tian Zhuang, Zhicheng Ji
· Briefings in Bioinformatics · 0 citations