A cascade-release microsphere-engineered injectable hydrogel enables immune remodeling and sustained chondrogenesis for facial cartilage regeneration.
Structural facial cartilage regeneration is impeded by limited intrinsic repair and injury-driven inflammatory remodeling, which promote fibrosis, matrix degradation, and phenotypic instability. Here, we report a temporally programmed immuno-chondrogenic hydrogel system that combines mesenchymal stem cells (MSCs) with...