It is demonstrated that CEBPB is a super-enhancer-driven gene, with all three isoforms (LAP1, LAP2, LIP) over-expressed in primary GBM, and elucidates a pathogenic axis in glioblastoma wherein OSM signaling and eIF4G2-mediated alternative translation converge on CEBPB isoforms to enforce enhancer architectures and chro...
Ji-Yang Liu, Ying Zhang, Xiao-Ping Yi et al.· Neuro-Oncology· 0 citations
This review critically evaluates recent mechanistic advances in CDK/cyclin biology and their pathological dysregulation across malignancies and highlights emerging approaches including proteolysis‐targeting chimeras, HSP90‐mediated targeting chimeras, hydrophobic tagging, molecular glues, and autophagy‐tethering compou...
MDM2 is an oncogenic E3 ubiquitin ligase best known for targeting the tumor suppressor p53 and is frequently amplified in human cancers, including dedifferentiated liposarcoma (DDLPS). We show that supraphysiological MDM2 expression can be exploited to reprogram its ligase activity toward selective degradation of o...
Ye Chen, Long Xie, Xian Guan et al.· Cell Death & Disease· 1 citation
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